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業績
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《学術論文》
31. Kasamatsu J and Kawakami K.
Immune System to Cryptococcal Infection and Immune Dysfunction
Leading to Putative Endogenous Reactivation.
Nippon Ishinkin Gakkai Zasshi, 63(3):47-58, 2022. (in Japanese)
30. Wang WL*, Kasamatsu J*, Joshita S*, Gilfillan S, Di Luccia B,
Panda SK, Kim DH, Desai P, Bando JK, Huang SC, Yomogida K,
Hoshino H, Fukushima M, Jacobsen EA, Van Dyken SJ, Ruedl C,
Cella M, Colonna M.
Proc Natl Acad Sci U S A., 119(23):e2204557119., 2022.
(*W.-L.W., J.K. and J.S. contributed equally to this work.)
本研究は東北大学プレスリリースで紹介されました．
29. Tanno H, Kanno E, Kurosaka S, Oikawa Y, Watanabe T, Sato K,
Kasamatsu J, Miyasaka T, Ishi S, Shoji M, Takagi N, Imai Y, Ishii K,
Tachi M, Kawakami K.
Topical Administration of Heat-Killed Enterococcus faecalis Strain KH2
Promotes Re-Epithelialization and Granulation Tissue Formation during
Skin Wound-Healing.
Biomedicines, 9(11):1520, 2021.
28. Sato K, Matsumoto I, Suzuki K, Tamura A, Shiraishi A, Kiyonari H,
Kasamatsu J, Yamamoto H, Miyasaka T, Tanno D, Miyahara A, Zong T,
Kagesawa T, Oniyama A, Kawamura K, Kitai Y, Umeki A, Kanno E,
Tanno H, Ishii K, Tsukita S, Kawakami K.
Deficiency of lung-specific claudin-18 leads to aggravated infection with
Cryptococcus deneoformans through dysregulation of the
microenvironment in lungs.
Sci Rep., 11(1):21110, 2021.
27. Kitai Y, Sato K, Tanno D, Yuan X, Umeki A, Kasamatsu J, Kanno E,
Tanno H, Hara H, Yamasaki S, Saijo S, Iwakura Y, Ishii K, Kawakami K.
Role of Dectin-2 in the Phagocytosis of Cryptococcus neoformans by
Dendritic Cells.
Infect Immun., 89(10):e0033021, 2021.
26. Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A,
Fujimura M, Kure S, Ishii N, Tominaga T.
Dysregulation of Rnf 213 gene contributes to T cell response via
antigen uptake, processing, and presentation.
J Cell Physiol., 236(11):7554-7564, 2021.
25. Tanno H, Kanno E, Sato S, Asao Y, Shimono M, Kurosaka S, Oikawa Y,
Ishi S, Shoji M, Sato K, Kasamatsu J, Miyasaka T, Yamamoto H, Ishii K,
Imai Y, Tachi M, Kawakami K.
Contribution of Invariant Natural Killer T Cells to the Clearance of
Pseudomonas aeruginosa from Skin Wounds.
Int J Mol Sci., 22(8):3931, 2021.
24. Yamamoto H, Tomiyama C, Sato K, Kasamatsu J, Takano K, Umeki A,
Nakahata N, Miyasaka T, Kanno E, Tanno H, Yamasaki S, Saijo S,
Iwakura Y, Ishii K, Kawakami K.
Dectin-2-mediated initiation of immune responses caused by influenza
virus hemagglutinin.
Biomed Res., 42(2):53-66, 2021.
23. Yamaguchi K, Kanno E, Tanno H, Sasaki A, Kitai Y, Miura T, Takagi N,
Shoji M, Kasamatsu J, Sato K, Sato Y, Niiyama M, Goto Y, Ishii K,
Imai Y, Saijo S, Iwakura Y, Tachi M, Kawakami K.
Distinct Roles for Dectin-1 and Dectin-2 in Skin Wound Healing and
Neutrophilic Inflammatory Responses.
J Invest Dermatol., 141(1):164-176, 2021.
22. Ishizuka S, Yokoyama R, Sato K, Shiroma R, Nakahira A, Yamamoto H,
Takano K, Kagesawa T, Miyasaka T, Kasamatsu J, Kanno E, Tanno H,
Ishii K, Kawakami K.
Effect of CARD9 Deficiency on Neutrophil-Mediated Host Defense
against Pulmonary Infection with Streptococcus pneumoniae.
Infect Immun., 89(1):e00305-20, 2020.
21. Sato Y, Sato K, Yamamoto H, Kasamatsu J, Miyasaka T, Tanno D,
Miyahara A, Kagesawa T, Oniyama A, Kawamura K, Yokoyama R,
Kitai Y, Umeki A, Ishizuka S, Takano K, Shiroma R, Nakahata N,
Kawakami K, Kanno E, Tanno H, Yamasaki S, Hara H, Ishii K,
Kawakami K.
Limited Role of Mincle in the Host Defense against Infection with
Cryptococcus deneoformans.
Infect Immun., 88(11):e00400-20, 2020.
20. Dobashi-Okuyama K, Kawakami K, Miyasaka T, Sato K, Ishii K,
Kawakami K, Masuda C, Suzuki S, Kasamatsu J, Yamamoto H,
Tanno D, Kanno E, Tanno H, Kawano T, Takayanagi M, Takahashi T,
Ohno I.
Novel Toll-Like Receptor 9 Agonist Derived from Cryptococcus
neoformans Attenuates Allergic Inflammation Leading to Asthma
Onset in Mice.
Int Arch Allergy Immunol., 181(9):651-664, 2020.
19. Sato K, Yamamoto H, Nomura T, Kasamatsu J, Miyasaka T, Tanno D,
Matsumoto I, Kagesawa T, Miyahara A, Zong T, Oniyama A,
Kawamura K, Yokoyama R, Kitai Y, Ishizuka S, Kanno E, Tanno H,
Suda H, Morita M, Yamamoto M, Iwakura Y, Ishii K, Kawakami K.
Production of IL-17A at Innate Immune Phase Leads to Decreased
Th1 Immune Response and Attenuated Host Defense against Infection
with Cryptococcus deneoformans.
J Immunol., 205(3):686-698., 2020.
18. Kanno E, Tanno H, Masaki A, Sasaki A, Sato N, Goto M, Shisai M,
Yamaguchi K, Takagi N, Shoji M, Kitai Y, Sato K, Kasamatsu J, Ishii K,
Miyasaka T, Kawakami K, Imai Y, Iwakura Y, Maruyama R, Tachi M,
Kawakami K.
Defect of Interferon γ Leads to Impaired Wound Healing through
Prolonged Neutrophilic Inflammatory Response and
Enhanced MMP-2Activation.
Int J Mol Sci., 20(22):5657, 2019.
17. Kasamatsu J*, Deng M*, Kasahara M, Matsumoto M, Seya T.
Comparative genomic and expression analysis of murine paired
triggering receptors expressed on myeloid cells.
BMC Immunol., 3;17(1):9, 2016.
16. Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M,
Ebihara T, Matsumoto M, Seya T.
INAM plays a critical role in IFN-γ production by NK cells
interacting with polyI:C-stimulated accessory cells.
J. Immunol., 15;193(10):5199-207, 2014.
15. Kasamatsu J*, Takahashi S*, Azuma M*, Matsumoto M,
Imamura M, Teshima T, Takahashi A, Hirohashi Y, Torigoe T,
Sato N Seya T.
HLA-A*2402/Kb transgenic mice induce a CD4+ T cell response
to mouse survivin with embedded human 2B peptide and
polyI:C.
Immunobiology, 220(1):74-82, 2014.
(*J.K., S.T. and M.A. contributed equally to this work.)
14. Kanda R, Sutoh Y, Kasamatsu J, Maenaka K, Kasahara M,
Ose T.
Crystal structure of the lamprey variable lymphocyte receptor C
reveals an unusual feature in its N-terminal capping module.
PLoS One. 23;9(1):e85875, 2014.
13. Kasamatsu J.
Evolution of innate and adaptive immune systems in jawless
vertebrates.
Microbiol Immunol. 57(1): 1-12, 2013.
12. Ng SY, Chow BK, Kasamatsu J, Kasahara M, Lee LT.
Agnathan VIP, PACAP and Their Receptors: Ancestral Origins
of Today's Highly Diversified Forms.
PLoS One. 7(9):e44691, 2012.
11. Seya T, Kasamatsu J, Azuma M, Shime H and Matsumoto M.
Natural killer cell activation secondary to innate pattern sensing.
Innate Immun. 3(3):264-73, 2011.
10. Ebihara T*, Azuma M*, Oshiumi H, Kasamatsu J, Iwabuchi K,
Matsumoto K, Saito H, Taniguchi T, Matsumoto M and Seya T.
Identification of INAM, a polyI:C-inducible membrane protein, that
participates in dendritic cell-mediated natural killer cell
activation.
J Exp Med. 207(12):2675-87, 2010.
(*T.E. and M.A. contributed equally to this work.)
9. Kasamatsu J*, Sutoh Y*, Fugo K, Otsuka N, Iwabuchi K,
Kasahara M.
Identification of a third variable lymphocyte receptor in the
lamprey.
Proc Natl Acad Sci USA. 10;107(32):14304-8, 2010.
(*J.K. and Y.S. contributed equally to this work.)
8. Kondo M, Maruoka T, Otsuka N, Kasamatsu J, Fugo K,
Hanzawa N, Kasahara M.
Comparative genomic analysis of mammalian NKG2D ligand
family genes provides insights into their origin and evolution.
Immunogenetics. 62(7):441-50, 2010.
7. Kasamatsu J, Oshiumi H, Matsumoto M, Kasahara M, Seya T.
Phylogenetic and expression analysis of lamprey toll-like
receptors.
Dev Comp Immunol. 34(8):855-65, 2010.
6. Kasahara M, Kasamatsu J, Sutoh Y.
Two types of antigen receptor systems in vertebrates.
Zoolog Sci. 25(10):969-75, 2008.
5. Holland LZ, Albalat R, Azumi K, Benito-Gutiérrez E, Blow MJ,
Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ,
Ferrier DE, Garcia-Fernàndez J, Gibson-Brown JJ, Gissi C,
Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H,
Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi
M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC,
Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA,
Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G,
Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood
N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye
Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de
Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N,
Holland PW.
The amphioxus genome illuminates vertebrate origins and
cephalochordate biology.
Genome Res. 18(7):1100-11, 2008.
4. Kasamatsu J, Suzuki T, Ishijima J, Matsuda Y, Kasahara M.
Two variable lymphocyte receptor genes of the inshore hagfish are
located far apart on the same chromosome.
Immunogenetics. 59(4):329-31, 2007.
3. Kim HM, Oh SC, Lim KJ, Kasamatsu J, Heo JY, Park BS, Lee
H, Yoo OJ, Kasahara M, Lee JO.
Structural diversity of the hagfish variable lymphocyte receptors.
J Biol Chem. 2;282(9):6726-32, 2007.
2. Pancer Z, Saha NR, Kasamatsu J, Suzuki T, Amemiya CT,
Kasahara M, Cooper MD.
Variable lymphocyte receptors in hagfish.
Proc Natl Acad Sci USA. 28;102(26):9224-9, 2005.
1. Kasamatsu J, Watanabe Y and Hanzawa N.
Genetic Variability of MHC Class II Beta 1 Genes in Far Eastern
Dace,Tribolodon hakonensis.
Mar Biotechnol. 6: S398-S403, 2004.
《著書（日本語）》
4. 笠松 純，瀬谷 司，笠原 正典．
「病原体認識戦略の進化」
『臨床免疫・アレルギー科』，科学評論社，56(1)，pp113-121, 2010.
3. 笠松 純，笠原 正典．
「高次機能形成の比較ゲノム：抗原認識戦略の多様性 -免疫系の比較
ゲノム解析から学ぶ-」
『比較ゲノム学から読み解く生命システム 基本概念から最新ゲノム情
報まで』，秀潤社，25(3)，pp87-96，2007.
2. 笠松 純，笠原 正典．
「Variable lymphocyte receptorの構造と機能」
『Annual Review 免疫 2007』，中外医学社，pp53-61，2006.
1. 笠松 純，笠原 正典．
「高次機能形成の比較ゲノム：適応免疫系の起源と多様性」
『細胞工学』，秀潤社，25(3)，pp298-303，2006
《賞罰》
5.LEGEND Research Grant Program 2022（2022年）
研究テーマ：「食物アレルギーにおける新規免疫抑制型好酸球サブセットの機能と免疫抑制機構の解明」
4. 第51回免疫学会総会 ベストプレゼンテーション賞（2022年）
Presentation No: WS20-19-O/P
The aryl hydrocarbon receptor instructs the immunomodulatory profile of a subset of Clec4a4+ eosinophils unique to the small intestine
Jun Kasamatsu (Kagoshima University / Washington University)
3. 第50回免疫学会総会 ベストプレゼンテーション賞（2021年）
Presentation No: 3-E-WS21-06-O/P
Placenta-expressed transcript-1, a novel immunosuppressive molecule, inhibits inflammatory cytokine production during bacterial infection.
Jun Kasamatsu (Tohoku University)
2. 日本生体防御学会 研究奨励賞（2011年）
受賞研究：無顎類を対象とした非自己認識レセプター群の同定
1. 北海道大学医学研究科 優秀論文賞（2011年）
受賞論文：Kasamatsu J*, Sutoh Y*, Fugo K, Otsuka N, Iwabuchi K,
Kasahara M.Identification of a third variable lymphocyte receptor
in the lamprey. Proc Natl Acad Sci USA. 10;107(32):14304-8, 2010.
(*J.K. and Y.S. contributed equally to this work.)